美国哈佛大学2023年招聘博士后职位（线粒体代谢物转运的生化机制）

美国哈佛大学2023年招聘博士后职位（线粒体代谢物转运的生化机制）

哈佛大学（Harvard University），简称“哈佛”，位于美国马萨诸塞州波士顿都市区剑桥市，一所顶尖私立研究型大学，常春藤盟校，全球大学校长论坛、全球大学高研院联盟成员。

哈佛大学建立于1636年，最早由马萨诸塞州殖民地立法机关创建，初名“新市民学院”。为了纪念在成立初期给予学院慷慨支持的约翰・哈佛牧师，学校于1639年3月更名为“哈佛学院（Harvard College）”。1780年，哈佛学院正式改称“哈佛大学”。

哈佛大学由十所学院以及一个高等研究所构成。该校还负责管理运行哈佛-史密松森天体物理中心、麻省总医院、波士顿儿童医院等机构。

2023年U.S. News美国最佳大学排名中，哈佛大学位列第3。截至2018年，哈佛共有18位菲尔兹奖得主，14位图灵奖得主。

Postdoctoral position in biochemical mechanisms of mitochondrial metabolite transport

Harvard University

Position

Details

Title Postdoctoral position in biochemical mechanisms of mitochondrial metabolite transport

School Harvard T.H. Chan School of Public Health Department/Area Molecular Metabolism Position Description

A postdoctoral position is available in the Kory lab in the Department of Molecular Metabolism at the Harvard T.H. Chan School of Public Health to investigate the biochemical mechanisms of mitochondrial metabolite transport.

We are looking for highly motivated individuals with a background in in vitro biochemistry, structural biology and/or biophysics to join our multi- disciplinary international team. The strong focus on molecular and mechanistic research in metabolism, cell biology and age-related diseases in the Department and the general excellence of biomedical research in the area provide an ideal environment for postdoctoral training with relevance to human health and disease. https: // www. hsph.harvard.edu/molecular-metabolism/

Research in the Kory lab focuses on the role of organelles in metabolic compartmentalization and regulation. Our current work centers on mitochondria, critical organelles in metabolism

generating both energy and precursors for biosynthesis. Beyond their metabolic roles, mitochondria are being recognized as important signaling hubs and mitochondrial dysfunction has been associated with major diseases including cancer, diabetes, and neurodegeneration. For mitochondria to function properly metabolites must be efficiently exchanged with the rest of the cell in a regulated manner. While metabolites can diffuse through pores in the outer membrane, the inner mitochondrial membrane is impermeable to most metabolites and separates two chemically contrasting environments.

The Kory lab takes multi-faceted approaches including biochemistry, structural biology, functional genomics, metabolite profiling, imaging and mouse models to determine how mitochondria achieve efficient metabolite exchange and conversion while maintaining the unique chemical environment of the mitochondrial matrix. Ultimately, we hope our research in understanding mitochondrial metabolite transport in humans will contribute to progress in the treatment of diseases with deregulated metabolism such as cancer and diabetes.

For more information, please visit: https: // kory-lab.com/

Basic Qualifications

The ideal candidate has a strong background in in vitro biochemistry, structure biology and/or biophysics and experience in methods and technologies such as protein expression and purification, thermostability assays, activity and binding assays, methods for protein structure determination, cross-linking mass spectrometry, and will join ongoing efforts in developing and applying systematic approaches to transporter identification and characterization.

Qualifications:

• Ph.D. in biological sciences, biophysics, biochemistry, or related field

• Motivation to understand metabolism, normal biology and disease at a mechanistic level

• Excellent communication, writing, and organizational skills

• In-depth biochemistry/Structural Biology/Biophysics experience

Additional Qualifications

Additional Qualifications or Expertise in any of the following areas is highly valued:

• Metabolomics, proteomics, mass spectrometry

• Microfluidics

• Microscopy

Special Instructions Contact Information

Dr. Nora Kory

Contact Email nkory@hsph.harvard.edu Equal Opportunity Employer

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law.

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